Teaching Hospitals NHS Foundation Trust HOME BASED THERAPEUTIC APPLICATION OF NON-INVASIVE POSTERIOR TIBIAL NERVE STIMULATION IN THE TREATMENT OF OVERACTIVE BLADDER SYMPTOMS: A PILOT CLINICAL TRIAL

Study design, materials and methods This parallel, randomized and home based pilot clinical trial was conducted between June 2013 and December 2014. Patients with idiopathic overactive bladder symptoms who had not responded or could not tolerate (due to side effects) conventional drug therapy, were randomized into one of three stimulation groups (unilateral PTNS, bilateral PTNS and sham stimulation). Participants were able to remain on stable medication throughout the trial and those with urinary retention, clinically significant voiding lower urinary tract symptoms or stress predominant mixed urinary incontinence were excluded. The participants had to present with at least 8 micturitions in the baseline in order to be randomized. The full list of inclusion and exclusion criteria and details of the trial is at trial registry.